I don't think there are any irredeemable themes or tropes, just ones that are waiting for a fresh eye. Horror, science fiction, and fantasy deal with the eternal verities, the subjects that have always - and will always - speak most deeply about who we are. That's why they're the most fascinating genres, and why they're always there to be reinvented. At the very least you can ask, 'This subject has been done to death now, so why are we so obsessed with it?' - and take a new angle from there.